Naphthoquinone Derivatives Exert Their Antitrypanosomal Activity via a Multi-Target Mechanism
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Naphthoquinone Derivatives Exert Their Antitrypanosomal Activity via a Multi-Target Mechanism
BACKGROUND AND METHODOLOGY Recently, we reported on a new class of naphthoquinone derivatives showing a promising anti-trypanosomatid profile in cell-based experiments. The lead of this series (B6, 2-phenoxy-1,4-naphthoquinone) showed an ED(50) of 80 nM against Trypanosoma brucei rhodesiense, and a selectivity index of 74 with respect to mammalian cells. A multitarget profile for this compound ...
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ژورنال
عنوان ژورنال: PLoS Neglected Tropical Diseases
سال: 2013
ISSN: 1935-2735
DOI: 10.1371/journal.pntd.0002012